What does the HAS-BLED score measure?
The HAS-BLED score estimates the 1-year risk of major bleeding in patients with atrial fibrillation who are being considered for or are already on oral anticoagulation. Major bleeding is defined as intracranial bleeding, hospitalization, a hemoglobin decrease of more than 2 g/L, and/or the need for blood transfusion. It was derived from a real-world cohort of 3,978 AF patients. See also our use the HAS-BLED Score Calculator.
What does each letter in HAS-BLED stand for?
H = Hypertension (uncontrolled, sBP > 160 mmHg), A = Abnormal renal and/or liver function (1 point each), S = Stroke history, B = Bleeding history or predisposition, L = Labile INR, E = Elderly (age > 65), D = Drugs (antiplatelets, NSAIDs) and/or alcohol use (1 point each). The maximum possible score is 9.
What HAS-BLED score indicates high bleeding risk?
A score of 3 or higher is considered high risk. According to the original validation data, patients with a HAS-BLED score ≥ 3 have a meaningfully elevated rate of major bleeding (approximately 3.74 bleeds per 100 patient-years) and should undergo regular clinical review after starting oral anticoagulation. A score of 0–1 is low risk and 2 is intermediate risk.
Should a high HAS-BLED score lead to stopping anticoagulation?
No — a high HAS-BLED score should not automatically lead to withholding anticoagulation. Instead, it should prompt identification and correction of modifiable bleeding risk factors (e.g., controlling blood pressure, reviewing interacting drugs, reducing alcohol intake). For most AF patients, the stroke prevention benefit of anticoagulation still outweighs the bleeding risk. You might also find our MCA Calculator (Middle Cerebral Artery) useful.
Does labile INR apply to patients on NOACs?
The labile INR criterion was developed in the context of warfarin therapy, where time in therapeutic range (TTR) < 60% is considered labile. For patients on direct oral anticoagulants (DOACs/NOACs), this criterion is generally not applicable, and some clinical guidance suggests scoring it as 0 for NOAC patients.
What counts as abnormal renal function in HAS-BLED?
Abnormal renal function is defined as the presence of chronic dialysis, renal transplantation, or a serum creatinine level ≥ 200 µmol/L (approximately ≥ 2.3 mg/dL). Each of renal and liver dysfunction scores 1 point independently, so a patient with both conditions scores 2 points for this criterion.
What counts as abnormal liver function in HAS-BLED?
Abnormal liver function is defined as chronic hepatic disease (e.g., cirrhosis) or biochemical evidence of significant hepatic derangement — bilirubin > 2× the upper limit of normal combined with AST, ALT, or ALP > 3× the upper limit of normal. Like renal dysfunction, it adds 1 point to the HAS-BLED score.
Which drugs predispose to bleeding in the HAS-BLED score?
The 'D' criterion for drugs refers to concomitant use of antiplatelet agents (such as aspirin or clopidogrel) and/or non-steroidal anti-inflammatory drugs (NSAIDs). Alcohol use of 8 or more drinks per week also counts as a separate 1-point component under the same criterion letter, with a combined maximum of 2 points.