How is LDL cholesterol calculated using the Friedewald equation?
The Friedewald equation estimates LDL as: LDL = Total Cholesterol − HDL − (Triglycerides ÷ 5). The triglycerides ÷ 5 portion estimates VLDL cholesterol. This formula was developed in 1972 and is the most widely used method in clinical labs worldwide. See also our use the LDL Cholesterol Calculator.
What is a normal LDL cholesterol level?
According to standard guidelines: below 100 mg/dL is optimal, 100–129 mg/dL is near optimal, 130–159 mg/dL is borderline high, 160–189 mg/dL is high, and 190 mg/dL or above is very high. Your target LDL may be lower (e.g. below 70 mg/dL) if you have heart disease or diabetes — always consult your doctor.
How do I calculate LDL with total cholesterol 230, HDL 47, and triglycerides 123?
Using the Friedewald equation: LDL = 230 − 47 − (123 ÷ 5) = 230 − 47 − 24.6 = 158.4 mg/dL. This falls in the 'borderline high' category and should be discussed with a healthcare provider.
How do I calculate total cholesterol from LDL and HDL?
Total cholesterol = LDL + HDL + VLDL (where VLDL ≈ Triglycerides ÷ 5). So if you know your LDL, HDL, and triglycerides, you can rearrange the formula: TC = LDL + HDL + (TG ÷ 5).
Are there limitations to the Friedewald equation?
Yes. The Friedewald equation is considered inaccurate when triglycerides exceed 400 mg/dL, in patients with type III hyperlipoproteinemia, or when chylomicrons are present (e.g. non-fasting samples). In these cases, direct LDL measurement is recommended. This calculator will flag values above 400 mg/dL.
How do I lower my LDL below 70 mg/dL?
Achieving LDL below 70 mg/dL typically requires a combination of dietary changes (reducing saturated and trans fats), regular aerobic exercise, and often statin medications. For very high-risk patients, additional therapies like PCSK9 inhibitors or ezetimibe may be prescribed by a cardiologist.
What is the difference between LDL and non-HDL cholesterol?
Non-HDL cholesterol includes all cholesterol carried by atherogenic (artery-clogging) particles — LDL, VLDL, IDL, and lipoprotein(a). It is calculated as Total Cholesterol − HDL. Non-HDL is considered a better predictor of cardiovascular risk than LDL alone, and its optimal level is generally 30 mg/dL higher than the target LDL.
Do I need to fast before a cholesterol test for this calculation to be valid?
Fasting (typically 9–12 hours) is traditionally recommended before a lipid panel because eating raises triglyceride levels, which affects the Friedewald LDL estimate. Many labs now perform non-fasting lipid panels, but the Friedewald formula is most accurate on fasting samples with triglycerides below 400 mg/dL. You might also find our ASCVD Risk Calculator useful.